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Zeige die Positionen als: truncated sexagesimal oder full sexagesimal oder dezimal
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www.bph.ruhr-uni-bochum.ded
Display positions in: truncated sexagesimal or full sexagesimal or decimal units
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www.bph.ruhr-uni-bochum.deDie durch Mitglieder der Bcl-2 Proteinfamilie regulierte Freisetzung von proapoptotischen Proteinen aus Mitochondrien gilt als Schlüsselereignis in der Apoptose.
Aktivierung des BH3-Proteins Bid durch spezifische Proteasen führt zur Bildung von "truncated" Bid (tBid), das nachfolgend die Insertion des Bcl-2 Proteins BAX in die Außenmembran von Mitochondrien induziert."Mitochondriales" BAX vermittelt schließlich die Freisetzung von Proteinen des mitochondrialen Intermembranraums in das Cytosol.
www.uni-stuttgart.deThe release of pro-apoptotic proteins from mitochondria is a key event in cell death signalling that is regulated by Bcl-2 family proteins.
Cleavage of the BH3-only protein Bid by multiple proteases leads to the formation of truncated Bid (tBid) which, in turn, promotes the insertion and oligomerization of Bcl-2 family protein BAX into the outer membrane of mitochondria, resulting in pore formation and release of proteins residing in the intermembrane space.
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